Really depends on your class, but as a M/W it is certainly better to use a 2h Staff
This is because magical Damage is a much greater factor of damage to a M/W as with all int/matk gear your matk will be high enough as is without the use of a talisman as well. The only way I could see wand+Tali is if the 2 choices between 2h and 1h that you have are less than a 10% difference in magical damage. In which case you can use a wand + fire damage tali statted int/matk

But I do not think that is currently the case so 2H all the way!!!
Some magical DPS classes that use wand rather staff-
W/M
D/R
M/R
Wl/R