Try pulling out the hidden folder "Runes of Magic" in the "My Documents" folder, see if that does anything. Dont have to delete it or anything, just drag it to your desktop and start up the game. What this does is make it so youre essentially loading up the client without any UI/User settings, the client automatically creates a new, clean slate, if you will.
See if doing that helps with being able to click/cast spells. If it does, then there was more than likely a corrupted save file (happens...a lot).
If that doesnt help, simply put in the folder back where it was and youll have your settings back. After that, I would try taking out your addons, as that is the next likely culprit.
Ravesden, D/S/Wd 80/75/62
Retired. Click siggy for old RoM vids, among other things.