the only true issue with disabled runes are block and shield.
if you think about it, we wanna be able to make them, ok. we want to be able to get hatred/recon when they aren't on special. those runes take soooooooo freakin many charges to make anything decent, there's no reason for them to be disabled.
takes block and shield to make recon and hatred. block is a nice rune. shield isn't, but hey, to make that rune you need...
crit, mdmg, pdmg and loot runes, by all means, as they add a substantial immediate advantage to classes. curse only shows up in the long term, i'm almost questioning why i made a curse VII instead of staying with curse VI.
but remember frogster, you're losing out on massive charges purchases by putting some of the essential runes on a disabled list. it takes far more than 199 dias to make some of these VI runes sometimes. and takes many, many, many more to make some of the insane ones.