...It's a sticky, lol, it can't really be necroed.
Anyway, as for the question at hand -- Broken down, if you're sure you want to be either a R/X or W/X, and your focus is PvE, I would stay away from R/P, R/D, W/P, W/D. None of these combos hold up well in PvE, though R/P is decent for PvP.
W/S is fun to play if you like AoEs, but it does fall way behind the top DPS combos for single-target damage; the gap might be smaller when the 70 elites come out. W/M is viable for damage now with the new elite. W/R, of course, is one of the best DPS combos in the game, so it's never a bad choice.
As for rogues, R/M as said above just got completely reworked, but a lot of the elites are not working as intended. Runesdatabase.com and theromwiki.com don't have the correct elite listings for that combo, so if those are the ones you're basing your interest off of, do a forum search for the new elites to see if you're still interested.
I don't know off hand how R/K is doing these days, since I really don't see many of them around. R/W is decent for damage, though one of its elites really needs to be updated for the current cap.
If you enjoy melee DPS, you might also want to check out wardens. I'm not familiar with how well W/Wl, W/Ch, R/Wl or R/Ch play out at higher levels, but you could consider some of those too if you don't mind playing a dwarf.